News

[ad_1] Explainer-What's new with the Fed's bank stress tests in 2022 [ad_2] Source link

[ad_1] The SARS-CoV-2 virus may increase the likelihood of the brain degeneration found in Parkinson’s disease, according to a study in mice. COVID-19 patients commonly report symptoms such as brain fog, headaches, and insomnia, complications which are not new after a viral infection, the researchers said. It took nearly a decade for patients to develop the neurological disease known as “post-encephalic parkinsonism” after the 1918 influenza pandemic, they said. The study, published in the journal Movement Disorders, found that the SARS-CoV-2 virus could raise the brain’s susceptibility to a toxin that causes the death of nerve cells seen in Parkinson’s disease. “Parkinson’s is a rare disease that affects 2 per cent of the population above 55 years, so the increase in risk is not necessarily a cause for panic,” said study first author Richard Smeyne, from Thomas Jefferson University, US.”But understanding how coronavirus impacts the brain can help us prepare for the long-term consequences of this pandemic,” Smeyne said. The study expands on prior findings from the Smeyne lab indicating that viruses can increase the susceptibility of brain cells or neurons to damage or death. In that study, the researchers discovered that mice exposed to the H1N1 influenza strain that caused the 2009 flu pandemic were more vulnerable to MPTP. MPTP is a toxin known to cause some of the characteristic symptoms of Parkinson’s disease, most notably the loss of neurons that express the chemical dopamine and increased inflammation in the basal ganglia, a brain region that is crucial for movement. The latest study employed mice that were genetically altered to express the human ACE-2 receptor, which the SARS-CoV-2 virus utilises to get access to the cells in our airways. These mice were infected with SARS-CoV-2 and then allowed to recover, the researchers said. The dosage used in this research corresponds to a mild COVID-19 infection in people, with around 80 per cent of infected mice surviving, they said. Thirty-eight days after the surviving mice had recovered, one group was given a modest dosage of MPTP that would not ordinarily trigger neuron loss. The control group was given saline. The animals were sacrificed and their brains were examined two weeks later. The researchers found that COVID-19 infection alone had no impact on dopaminergic neurons in the basal ganglia. However, mice given a modest dosage of MPTP after recovering from infection demonstrated the classic pattern of neuron loss found in Parkinson’s disease.This increased sensitivity following COVID-19 infection was comparable to what was reported in the influenza trial, suggesting that both viruses might cause an equal increase in the risk of developing Parkinson’s. “We think about a ‘multi-hit’ hypothesis for Parkinson’s — the virus itself does not kill the neurons, but it does make them more susceptible to a ‘second hit’, such as a toxin or bacteria or even an underlying genetic mutation,” Smeyne explained.Both influenza and SARS-CoV2 have been found to cause a “cytokine storm” or an overproduction of pro-inflammatory chemicals. These chemicals can cross the blood-brain barrier and activate the brain’s immune cells – microglia. The researchers found increased numbers of activated microglia in the basal ganglia of mice that recovered from SARS-CoV2 and received MPTP. While the mechanism is not fully understood, they believe the increased microglia inflame the basal ganglia and cause cellular stress. This then lowers the neurons’ threshold to withstand subsequent stress. “We were concerned about the long-term consequences of viral infection,” said Peter Schmidt, a neuroscientist from New York University in the US, who co-led the study. The researchers are planning to determine whether vaccines can mitigate the experimental increase in Parkinson’s pathology linked to prior SARS-CoV-2 infection.They are also testing other variants of the virus, as well as doses that correspond to milder cases in humans. [ad_2] Source link

[ad_1] Need new luggage? Here’s a great deal! Walmart has this Protege 3 Piece Luggage Set for just $34.77 right now! This includes a 24″ check bag, 22″ duffel bag, and a boarding tote. There are four color options. Shipping is free on orders over $35. Otherwise, choose free in-store pickup. Thanks, Hip2Save! [ad_2] Source link

[ad_1] Iran blames U.S. for stalled talks with world powers to revive 2015 nuclear deal [ad_2] Source link

[ad_1] Congress leader Rahul Gandhi appeared before the Enforcement Directorate for the fourth time today in connection with the National Herald money-laundering case. After three straight days of questioning last week, the ED had allowed Gandhi’s request to defer his questioning till today owing to his mother Sonia Gandhi’s hospitalisation. The 51-year-old former Congress chief arrived at the ED headquarters on APJ Abdul Kalam Road in central Delhi at 11.05 AM with his “Z+” category CRPF security escort. A huge contingent of police and paramilitary personnel was deployed around the federal agency’s office even as Section 144 of the Code of Criminal Procedure (CrPC) has been imposed in the area like last week.  Meanwhile, top party leaders, including Mallikarjun Kharge, Salman Khurshid, K Suresh and V Narayanasamy sat on a ‘Satyagraha’ to protest against the ED action on Gandhis and the Centre’s ‘Agnipath’ recruitment scheme. The party on Sunday said lakhs of its workers will hold peaceful protests today against the Modi government’s “vendetta politics” in targeting Gandhi and the Centre’s “anti-youth” Agnipath scheme.  Congress leader Ajay Maken today said that the party will hold Satyagraha at Delhi’s Jantar Mantar and a party delegation will meet President Ram Nath Kovind at 5 pm to demand withdrawal of Agnipath scheme. Delhi | Congress leaders, including Mallikarjun Kharge, Salman Khurshid, K Suresh, V Narayanasamy and others, hold a 'Satyagraha' at Jantar Mantar against ED summons to Rahul Gandhi and #AgnipathScheme pic.twitter.com/TbTWnanZww — ANI (@ANI) June 20, 2022 The party on Sunday said it will also bring to the President’s notice the alleged manhandling and harassment of party MPs by the Delhi Police during their protests against Rahul Gandhi’s questioning by the ED in the money laundering case. Senior Congress leaders, including Leader of Opposition in Rajya Sabha Mallikarjun Kharge, party’s leader in Lok Sabha Adhir Ranjan Chowdhury, P Chidambaram, K C Venugopal and Ramesh, are set to meet meet Kovind and apprise him about the “unprovoked manhandling” of party MPs, which it alleged was in violation of all democratic norms.  Separate delegations of Congress leaders have already met Rajya Sabha chairman and Vice President M Venkaiah Naidu and Lok Sabha Speaker Om Birla and have sought action for violation of the rights of MPs and asked them to treat the same as privilege notices. The Congress had put up strong protests against the ED’s questioning. The police had imposed prohibitory orders in central Delhi ahead of the Congress’ protest and also amid the Bharat Bandh called by protesters against the Centre’s Agnipath recruitment scheme. Traffic curbs have also been put in place in several parts of central Delhi. In a series of tweets on Monday, the Delhi Traffic Police informed commuters about road closures.Due to special traffic arrangements, inward movement of buses will be restricted in New Delhi beyond Gol Dak Khana Junction, Patel Chowk, Windsor Place, Teen Murti Chowk and Prithviraj Road, it said. “Kindly avoid Gol Methi junction, Tughlak Road Junction, Claridges Junction, Q-point Junction, Sunehri Masjid Junction, Maulana Azad Road Junction & Man Singh Road Junction between 0800 hrs & 1200 hrs. Due to special arrangements there will be heavy traffic movement on these roads,” it added. The traffic police also advised commuters to avoid Motilal Nehru Marg, Akbar Road, Janpath and Man Singh Road between 8 am and 12 pm. Rahul Gandhi had appealed to party leaders and workers not to celebrate his birthday on Sunday. In a message to them, he had said Saturday night that the youngsters of the country were anguished and protesting on the streets and the Congress workers should stand with them. However, some leaders had put up hoardings in some places wishing him on his birthday. Gandhi, in a tweet, on Sunday thanked all who extended wishes to him on his birthday. [ad_2] Source link

[ad_1] This 3 Pieces Folding Wooden Picnic Table Bench Set is so practical! Costway has this 3 Pieces Folding Wooden Picnic Table Bench Set on sale for just $159 shipped right now (regularly $318)! Plus, use the promo code SUM30OFF to score an extra 30% off making it just $129 shipped! This picnic table set comes with a rectangular table and 2 benches, which offers a great place to drink beer or enjoy outdoor leisure time in your garden. The set accommodates 4 people, ideal for family reunion or friends gathering. Valid through June 30, 2022. Thanks, Hip2Save! [ad_2] Source link

[ad_1] Crypto industry gripped by anxiety as bitcoin wobbles near key $20,000 level [ad_2] Source link

[ad_1] Bharat Bandh Live News Updates, Agneepath Scheme Protests Latest News: Precautionary measures are in place across states ahead of today’s Bharat Bandh call given by Army job aspirants protesting against the Centre’s ‘Agnipath’ scheme. The Gautam Buddh Nagar Police has imposed CrPC Section 144 in the district and asked people to not engage in any activity which disrupts law and order. Jaipur Police has also imposed Section 144, banning gathering of more than four people.   The government, on the other hand, has stood firm over the rollout of the scheme for short-term recruitment in the Armed forces. The three services of the military on Sunday came out with a broad schedule of enrolment under the new policy and warned those who indulged in violence and arson will not be inducted. [ad_2] Source link

[ad_1] Grab this LEGO Friends Forest Waterfall Building Kit for a gift idea! Amazon has this LEGO Friends Forest Waterfall Building Kit for just $6.99! A great gift idea on a budget! Sign up for a free trial of Amazon Prime to get free two-day shipping (and possibly one-day or same-day shipping!) with no minimum. If you’re not sure Prime is worth it, read this post for some helpful info to help you decide! And don’t forget you can sign up for Swagbucks to earn free gift cards to use on Amazon deals! [ad_2] Source link

[ad_1] Asia shares edge up with Wall St futures, mood fragile [ad_2] Source link